At the beginning of 2018, SPHN and the five Swiss university hospitals signed collaboration agreements to establish interoperable clinical data management systems for research (clinical data warehouse, CDW). A CDW has been established at the University Hospital of Basel and is being constantly expanded. It consists of an IT platform that consolidates clinical datasets, stored in several clinical information systems, presents them to the researchers and clinicians in an interoperable form and connects them to other -omics data and biobanking samples. The CDW represents a key pillar for data-driven medicine to the benefit of patients, research and health care management.

During the first phase of the SPHN activities (2017-2021) researchers/clinicians from Basel were involved in 16 national SPHN-funded projects (9 Driver Projects and 7 Infrastructure Development Projects) which are now successfully concluded or are in the conclusion phase.

SPHN has now started its second funding phase (2021-2024). On the road towards establishing a Swiss personalized health ecosystem, SPHN, together with its complementary initiative from the ETH Domain Personalized Health and Related Technologies (PHRT), have launched a joint call for proposals for National Data Streams (NDS). This new format provides funding to multidisciplinary consortia that invest in sustainable and reusable health-related data infrastructure development in conjunction with high-end research. An NDS will work across the value chain from biomedical research to personalized health and clinical application to address which, and in what form, data can support clinical decision-making for the benefit of patients. With the support of PHB, ten outline NDS proposals with Basel involved have been submitted, out of which four NDS have been selected for funding from 2022 to 2025.

In 2022, SPHN launched also a Call for Demonstrator projects. These projects will test the infrastructures, processes, and data resources established in the realm of SPHN to demonstrate their added value for the network and to identify the remaining gaps. From a total of 30 project applications, 11 Demonstrator projects were selected for funding. Two types of Demonstrator projects are supported: On the one hand, projects that test the practical application of SPHN infrastructure components in medical research and/or expand their use in the network. On the other hand, projects that demonstrate the added value of SPHN-compliant data resources from the university hospitals for personalized health research. The SPHN International Advisory Board (IAB) selected the supported projects based on the following main criteria: use of SPHN infrastructures, added value for the network and personalized health research, and feasibility.