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University of Basel

11 June 2019

Learning from Nature’s Bounty: New Libraries for Drug discovery

An artistic depiction of a macrocycle binding to a target protein. (Image: University of Basel, Basilius Sauter | CC BY-SA 3.0)
An artistic depiction of a macrocycle binding to a target protein. (Image: University of Basel, Basilius Sauter | CC BY-SA 3.0)

Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult to emulate and build on Nature’s success in the laboratory. By completing a complex molecular synthesis of these compounds attached to a unique identifying DNA strand, the Chemists of the University of Basel have built a rich collection of natural product-like macrocycles that can be mined for new medicines as the researchers report in the scientific journal “Angewandte Chemie”.

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