18 Jan 2018
10:30 - 11:15
Biozentrum/Pharmazentrum, PZ HS 2, Klingelbergstrasse 50-70, Basel
Type VI secretion system: from the discovery to the mode of action of a dynamic bacterial nanomachine
Vortrag von Prof. Dr. Marek Basler, University of Basel, Biozentrum, Switzerland
Bacteria have evolved several nanomachines to deliver proteins from their cytosol to target cells. These nanomachines differ in their structure, regulation, secreted substrates and are essential for bacterial survival in different environments. In my talk, I will describe the journey from the discovery of the Type VI secretion system (T6SS) to the current understanding of its structure, dynamics and mode of action. I will explain how we used a combination of live-cell imaging, cryo-electron microscopy and genetics to show that T6SS works as a powerful speargun to force large proteins across cell envelopes of both eukaryotic and bacterial cells. I will provide evidence that T6SS structure is evolutionarily related to contractile phage tails and show that subcellular localization of T6SS assembly is in many bacteria regulated with a remarkable precision with implications for its function. I will discuss how T6SS influences bacterial pathogenesis, competition and horizontal gene transfer and thus impacts human health.
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