Currently no treatment option is available for five percent of patients suffering from chronic myelogenous leukemia, since they have developed resistance to conventional medications. Prof. Stephan Grzesiek’s group at the Biozentrum of the University of Basel, in collaboration with Dr. Wolfgang Jahnke and colleagues from Novartis, has investigated the combined action of two different compounds against this form of leukemia. They have been able to explain at the atomic level, how both substances alter the structure of an enzyme and how their combination potentially can overcome drug resistance.
Physicists at the University of Basel have been successful in generating photons – the quantum particles of light – with only one color. This is useful for quantum information. The scientists have actively stabilized the wavelength of the photons emitted by a semiconductor thereby neutralizing the charge noise in the semiconductor.
The Eckenstein-Geigy Professorship in Pediatric Pharmacology at the University of Basel and the University Children’s Hospital Basel (UKBB) is no longer vacant: The University Council appointed Prof. Johannes van den Anker for the beginning of 2014.
The Institute of Nursing Science at the University of Basel has comprehensively examined the work and personnel situation in a representative sample of Swiss nursing homes. The Swiss Nursing Homes Human Resources Project (SHURP) surveyed 5,323 professional care workers in 163 nursing homes. The results showed high quality of nursing care and that staff enjoys their current job. However, the study also identified the high professional and physical demands nursing care staffs face as well as the difficulties in recruiting qualified nursing personnel.
Through analysis of the human genome, Basle scientists have identified molecules and compounds that are related to human memory. In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories.
Alpine plants that survived the Ice Ages in different locations still show accrued differences in appearance and features. These findings were made by botanists from the University of Basel using two plant species. So far, it was only known that the glacial climate changes had left a «genetic fingerprint» in the DNA of alpine plants.
Cold seeps are the basis for a surprising diversity in the desert-like deep sea. Off the coast of Costa Rica, an international team involving Geomar Helmholtz Centre for Ocean Research Kiel, University of Basel and Max Planck Institute for Marine Microbiology, documented lithodid crabs of the genus Paralomis sp. grazing bacterial mats at a methane seep. The scientists' analysis results and a time-lapse video, published in the online journal Plos One, show that not only sessile organisms benefit from the productivity around the cold seeps.
To gain complete control over chemical reactions is one of the main goals of chemists around the world. For the first time, scientists at the University of Basel and the Center of Free-Electron Laser Science in Hamburg were able to successfully sort out single forms of molecules with electric fields and have them react specifically. Analysis of the reaction rates showed a relation between the spatial structure of the sorted molecules and their chemical reactivity.
The outer membrane of bacteria contains many proteins that form tiny pores. They are important for absorbing nutrients and transmitting signals into the cell. A research group at the University of Basel’s Biozentrum has now shown for the first time at atomic resolution, that these pore proteins are transported in an unstructured, constantly changing state to the outer bacterial membrane.