Our immune system must distinguish between self and foreign and in order to fight infections without damaging the body's own cells at the same time. The immune system is loyal to cells in the body, but how this works is not fully understood. Researchers in the Department of Biomedicine at the University Hospital and the University of Basel have discovered that the immune system uses a molecular biological clock to target intolerant T cells during their maturation process.
Researchers at the University of Basel have succeeded in observing the “forbidden” infrared spectrum of a charged molecule for the first time. These extremely weak spectra offer perspectives for extremely precise measurements of molecular properties and may also contribute to the development of molecular clocks and quantum technology.
Human articular cartilage defects can be treated with nasal septum cells. Researchers at the University and the University Hospital of Basel report that cells taken from the nasal septum are able to adapt to the environment of the knee joint and can thus repair articular cartilage defects.
Advances in the treatment of muscular dystrophy: For the first time, a research team has succeeded in restoring a missing repair protein in skeletal muscle of patients with muscular dystrophy.
In case of an inflammation the body releases substances that increase the immune defense. During chronic inflammation, this immune response gets out of control and can induce organ damage. A research group from the Department of Biomedicine at the University and the University Children’s Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation. These lymphoid cells are thus an important target for the treatment of infection and chronic inflammation.
Whether pneumonia or sepsis – infectious diseases are becoming increasingly difficult to treat. One reason for this is the growing antibiotic resistance. But even non-resistant bacteria can survive antibiotics for some time, and that’s why treatments need to be continued for several days or weeks. Scientists at the Biozentrum of the University of Basel showed that bacteria with vastly different antibiotic sensitivity coexist within the same tissue. In the scientific journal Cell they report that, in particular, slowly growing pathogens hamper treatment.
The protein mTOR is a central controller of growth and metabolism. Deregulation of mTOR signaling increases the risk of developing metabolic diseases such as diabetes, obesity and cancer. In the current issue of the journal Proceedings of the National Academy of Sciences, researchers from the Biozentrum of the University of Basel describe how aberrant mTOR signaling in the liver not only affects hepatic metabolism but also whole body physiology.
A research team from the University of Basel made a surprising find in a Neolithic settlement at the boarders of Lake Biel in Switzerland: The DNA of a cattle bone shows genetic traces of the European aurochs and thus adds a further facet to the history of cattle domestication. The journal Scientific Reports has published the results.
The manipulation of atoms has reached a new level: Together with teams from Finland and Japan, physicists from the University of Basel were able to place 20 single atoms on a fully insulated surface at room temperature to form the smallest “Swiss cross”, thus taking a big step towards next generation atomic-scale storage devices.