Researchers at the University of Basel have successfully developed artificial organelles that are able to support the reduction of toxic oxygen compounds. This opens up new ways in the development of novel drugs that can influence pathological states directly inside the cell.
University of Basel Researchers have identified a new class of selectin antagonists as lead structures for anti-inflammatory drugs. Their results were recently published in the Journal of the American Chemical Society.
In the process of metastasis, the movement of cancer cells to different parts of the body, a specific master regulator gene plays a central role: a transcription factor named Sox4 activates a sequence of genes and triggers the formidable process. This finding is reported by researchers from the University of Basel and from the Friedrich Miescher Institute in Cancer Cell. Inhibition of Sox4 and subsequent processes may prevent metastasis in cancer patients.
The fusion of blood vessels during the formation of the vascular system follows a uniform process. In this process, the blood vessels involved go through different phases of a common choreography, in which the splitting and the rearrangement of endothelial cells play a critical role. Markus Affolter`s research group at the Biozentrum, University of Basel, has been able to demonstrate this in a living organism, the zebrafish.
Medullary thymic epithelial cells (mTECs) allow the thymus to ensure that the body’s T cells are able to distinguish between potentially harmful foreign antigens and those that are produced by the body itself. A Swiss-Japanese research team suggests that mTECs do not share a common progenitor with cortical-thymic TECs (cTECs) that produce T cells, but may actually evolve from them.
Researchers at the University of Basel have found evidence that the inheritance of resistance in water fleas against a given bacterium is based on a few genes. A single change in these genes can completely reverse the outcome of an infection, thus lending empirical support to a key assumption of co-evolutionary models.