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University of Basel

07 January 2022

The neuronal mechanism behind motivation

Neurons
What happens in the brain of a mouse when it acts to reach a certain goal? (Symbolic image: Birth Into Being / Flickr CC BY-NC-SA 2.0)

Our actions are motivated by the goals we want to achieve. However, little is known about the mechanism in our brains that allow us to make the right decisions to reach our goals. Researchers at the Friedrich Miescher Institute for Biomedical Research (FMI) and the University of Basel now identified the sequence of events taking place in a mouse brain when the mouse behaves in a certain way to obtain a reward. And how it can adapt its behavior when the reward is not the one expected.

If you go to a bakery every day solely to buy a specific bread, you will stop going to that bakery once you learnt that it doesn’t sell your favorite bread anymore. This is called goal-directed behavior, and the amygdala – the small almond-shape emotion processing center in the brain – is known to be involved in controlling that.

So far, the role of the amygdala has been investigated in mice in so-called cue-directed behavior, when a visual or auditory cue (e.g. a sound) is the signal that something is going to happen (e.g. the mouse will receive some sugar) and make the mouse behave in a certain way (e.g. it will go to the place in the cage where it receives the sugar). How the amygdala is involved in goal-directed behavior however – when mice do something without cues, at their own pace to achieve a goal – has been unclear.

In a study published in Science, Julien Courtin, a postdoc in the group of Professor Andreas Lüthi, trained mice in a goal-directed task: Over the course of several days, the animals learnt that when they pushed one lever, they received a drop of sucrose, and when they pushed another lever, they received a drop of milk.

Sequence of images of a mouse pressing a lever to receive a reward
When a mouse presses a lever to obtain a reward, various populations of neurons are active in its brain; those depend on the specifics of the goal that the mouse has in mind. (Image: FMI)

Once the animals were experts in conducting these tasks, Courtin adapted the experimental set-up: He gave the mice the reward without having them press the lever; or he had them press the lever without reward; or he allowed the mice to stuff themselves with one of the rewards. During all these various actions performed by the mice, Courtin recorded their brain activity in the amygdala and, together with Yael Bitterman, a computational neuroscientist in the Lüthi lab, developed new analytical methods to decipher the underlying neuronal code.

A prediction machine

Courtin and Bitterman, the co-first authors of the study, identified the distinct populations of neurons in the amygdala involved in the various aspects of this goal-directed behavior. For example, they showed that a certain population of neurons were active when the mouse pressed lever 1 to expect reward 1. But once lever 1 was not associated with the reward anymore, this population of neurons lost its activity. “The population of neurons was not active because the mouse pressed the lever, but because the lever was associated with the expectation of the reward,” says Courtin. “As the mouse learnt not to expect a reward anymore, this population disappeared,” he adds.

Most remarkably, the results show that not only the type of reward, its size and the likelihood that it will happen, is represented in the amygdala, but also its value – a flexible parameter that depends on many factors (e.g. how hungry the mouse is). The amygdala ships all this information to other brain regions, which then use it to make appropriate decisions and adapt the behavior according to the possible rewards.

This news is based on a press release issued by the FMI.


Original publication

J. Courtin, Y. Bitterman, S. Müller, J. Hinz, K. M. Hagihara, C. Müller & A. Lüthi.
A neuronal mechanism for motivational control of behavior.
Science (2022), doi: 10.1126/science.abg7277

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