14 Mar 2018
11:00 - 12:00
Biozentrum/Pharmazentrum, PZ HS 2, Klingelbergstrasse 50-70, Basel
Sensing the matrix: transducing mechanical signals from integrins to the nucleus
Vortrag von Prof. Dr. Pere Roca-Cusachs, Institute for Bioengineering of Catalonia (IBEC) and University of Barcelona, Spain
Cell proliferation and di?erentiation, as well as key processes in development, tumorigenesis, and wound healing, are strongly determined by the properties of the extracellular matrix (ECM), including its mechanical rigidity and the density and distribution of its ligands. In this talk, I will explain how we combine molecular biology, biophysical measurements, and theoretical modelling to understand the mechanisms by which cells sense and respond to matrix properties. I will discuss how the properties under force of integrin-ECM bonds, and of the adaptor protein talin, drive and regulate matrix sensing. I will further discuss how this sensing can be understood through a computational molecular clutch model, which can quantitatively predict the role of integrins, talin, myosin, and ECM receptors, and their e?ect on cell response. Finally, I will analyze how signals triggered by rigidity at cell-ECM adhesions are transmitted to the nucleus, leading to the activation of the transcriptional regulator YAP.
Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School at the University of Barcelona. He then worked in the lab of Prof. Michael Sheetz (Department of Biological Sciences, Columbia University) as a post-doctoral researcher until 2011. In 2011, He joined the University of Barcelona, where he is now an associate professor. In 2012, he obtained a joint position as group leader at the Institute for Bioengineering of Catalonia (IBEC). He is a recipient of the EMBO Young Investigator Award. The research of his group focuses on unraveling the physical and molecular mechanisms by which cells detect and respond to mechanical force.
1. R. Oria et al., Force loading explains spatial sensing of ligands by cells. Nature 552 219 (2017) 2. Elosegui-Artola et al., Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell 171 1397 (2017)
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