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PHB Oncology Cluster
Cancer is a genomic disease that varies in its genetic and epigenetic aberrations between tumors of individual patients with even the same cancer type. The currently prevalent "one size fits all" perception for drug dosing and treatment has been proven to achieve only limited therapeutic success, highlighting the need for a more comprehensive molecular and cellular analysis of the tumor and of the treatment-related changes. The benefit of analysing molecular and cellular features in tumors of individual patients will not only advance clinical drug testing but also substantially improve the development and implementation of rational and personalized treatment strategies for the population.
The goal of our cluster is to create a world-class multidisciplinary center for translational research in Personalized Health medicine in the cancer field. Our cluster brings together all disciplines involved in cancer research in the Basel area relevant to the Personalized Health initiative, including but not limited to basic and clinical laboratory research, clinical oncology, surgery, pathology, radiology and nuclear medicine, epidemiology, computational biology, pharmacology, nanoscience, drug development and delivery. Our local research cluster also strongly collaborates with the partner leading institutions in Zürich through the PH Alliance Zürich-Basel.
Our aim is to provide a nationally and internationally recognized platform for data integration, multi-level communication, education and training and, most importantly, it will also be the condensation core for research projects that tackle the molecular and cellular defects underlying carcinogenesis and improve patient diagnosis and treatment using an interdisciplinary and multi-institutional approach.
PHB Oncology Cluster Chairs
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University of Basel - Dept. of Biomedicine
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PD Dr. med. Dr. phil. Andreas Wicki
University Hospital of Basel
PHB Oncology Cluster Members
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Prof. Nicola Aceto
University of Basel - Dept. of Biomedicine
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Prof. Niko Beerenwinkel
ETH, D-BSSE
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Prof. Karsten Borgwardt
ETH, D-BSSE
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Prof. Gerhard M. Christofori
University of Basel - Dept. of Biomedicine
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Prof. Michael Hall
University of Basel - Biozentrum
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Prof. Markus Heim
University of Basel - Dept. of Biomedicine
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Prof. Viola Heinzelmann
University of Basel - Dept. of Biomedicine
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Prof. Viviane Hess
University Hospital of Basel
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Prof. Dagmar Iber
ETH, D-BSSE
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PD Dr. Benjamin Kasenda
University Hospital of Basel
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PD Dr. Christian Kurzeder
University Hospital of Basel
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Prof. Claudia Lengerke
University of Basel - Dept. of Biomedicine
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Prof. Ernst Meyer
University of Basel - Dept. of Physics
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PD Dr. Cyrill Rentsch
University Hospital of Basel
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Prof. Christoph Rochlitz
University Hospital of Basel
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Prof. Primo Leo Schär
University of Basel - Dept. of Biomedicine
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Prof. Timm Schroeder
ETH, D-BSSE
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Prof. Jürg Schwaller
University of Basel - Dept. of Biomedicine
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Prof. Torsten Schwede
University of Basel, SIB, SPHN-DCC
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Prof. Radek Skoda
University of Basel - Dept. of Biomedicine
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PD Dr. Simone Münst Soysal
University Hospital of Basel
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Dr. Michael Stadler
Friedrich Miescher Institute
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Dr. Bram Stieltjes
University Hospital of Basel
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Prof. Luigi Terracciano
University Hospital of Basel
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Prof. Walter Weber
University Hospital of Basel
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Prof. Matthias P. Wymann
University of Basel - Dept. of Biomedicine
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Prof. Alfred Zippelius
University of Basel - Dept. of Biomedicine
SPHN call 2017: Swiss Personalized Oncology (SPO) Driver Project
Integrating clinical and molecular information from large number of cancer patients will enable more precise diagnoses and treatments tailored to the individual patient. The main goal of the Swiss Personalized Oncology (SPO) Driver Project led by Prof. Mohamed Bentires-Alj (University of Basel) and Prof. Olivier Michielin (CHUV) is to achieve Switzerland-wide interoperability of the clinical and laboratory data from cancer patients. To overcome the current bottlenecks of fragmented and unstructured data, we will harmonize data on diagnoses, treatments and outcomes of cancer patients through the SPHN data warehouse infrastructures and a web-based system for non-university cancer clinics. We will further standardize the molecular profiling of tumor biopsies to enable research for predictive biomarkers. A Swiss Molecular Tumor Board will leverage the analysis and discussion of complex cancer patient cases and play an instrumental role in the nation-wide harmonization efforts to enable innovative research delivering novel and better treatment algorithms for cancer patients.
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Contact informationProf. Dr. Mohamed Bentires-Alj
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Contact informationDr. Cristina Golfieri
Coordinator PHB Research Clusters - Manager PHB (ad interim)
